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Highlights: • The role of modern analytical chemistry is essential in exposure science. • Hyphenation of chromatography and HRMS allows the identification of many organic contaminants in the aquatic environment. • Different strategies (target, suspect, non-target) are used for the broad investigation of emerging chemical risks in water. • Monitoring programs and risks assessments are normally focused on parent contaminants. • Little information exists on occurrence and (eco)toxicological effects of transformation products/metabolites in water.
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