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ABSTRACT - [...] This paper describes a case study to explore and illustrate read-across of genotoxicity data by following the “Recommendations for nanomaterials applicable to the Guidance on QSARs and Grouping”, developed by the European Chemicals Agency (ECHA). The grouping hypothesis was supported by the use of chemoinformatics techniques such as hierarchical clustering and principal components analysis. The uncertainties of the present case study were evaluated using the Read-Across Assessment Framework (RAAF) developed by ECHA.
[...] This study shows the practical application of the ECHA framework for grouping of nanomaterials (NMs) as well as
SOURCE sciencedirect.com
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