Improving tests for developmental neurotoxicity

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The National Toxicology Program (NTP) evaluated a battery of cell-based and nontraditional animal models to predict the effects of various chemicals on development of the human neurological system. A collection of eight journal articles, published together in the January issue of Toxicological Sciences (see sidebar), described different aspects of the initiative.

“Over the past decade, there has been increased recognition of the need to develop more and better methods to rapidly identify compounds that have the potential for developmental neurotoxicology,” said Mamta Behl, Ph.D., from the NTP Toxicology Branch. Behl led the effort and is first author on the overview article and co-author of three companion articles in the journal collection.

“There is a pressing need to demonstrate the utility and limitations of these approaches so that they can be put into effect as soon as possible, especially in the context of prioritizing chemicals for further in-depth evaluation to help protect public health,” she added.



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