Chemicals Listed as Known to the State of California to Cause Reproductive Toxicity: Chlorpyrifos and n-Hexane (updated)

Effective December 15, 2017, the Office of Environmental Health Hazard Assessment (OEHHA) is adding  chlorpyrifos (CAS No. 2921-88-2) and n-hexane (CAS No. 110-54-3) to the list of chemicals known to the state to cause reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65).  Chlorpyrifos and n-hexane were considered by the Developmental and Reproductive Toxicant Identification Committee (DARTIC) in its official capacity as the “state’s qualified experts” at a public meeting held on November 29, 2017.  The DARTIC determined that chlorpyrifos was clearly shown through scientifically valid testing according to generally accepted principles to cause reproductive toxicity, based on the developmental endpoint.  The committee also determined that  was clearly shown through scientifically valid testing according to generally accepted principles to cause reproductive toxicity, based on the male reproductive endpoint.  Regulations for the listing of chemicals by the DARTIC are set out in Title 27, California Code of Regulations, section 25305(b)(1).

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