Animal-free method predicts nanoparticle toxicity for safer industrial materials


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Our lungs are exposed to a multitude of hazardous airborne particles on a daily basis. Nanoparticles, due to their small size, may reach the sensitive alveolar region of the human lung and trigger inflammation even after a single inhalation leading to severe diseases such as heart disease, brain damage and lung cancer for prolonged exposure. In manufacturing, toxic nanoparticles may be released into the environment during the production, processing, degradation or combustion of materials. Despite advances in models for nanotoxicology, currently neither in vitro nor in silico testing tools can reliably predict adverse outcomes or replace in vivo testing. In order to facilitate the introduction of safer materials into our lives, novel testing strategies are needed to predict the potential toxicity of industrial nanoparticles before and during the manufacturing process.

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