Discover how Chemycal PRO helps you boosting your regulatory monitoring:
ABSTRACT - The shortage of data on non-intentionally added substances (NIAS) present in food contact material (FCM) limits the ability to ensure food safety. Recent strategies in analytical method development permit NIAS investigation by using chemical exploration, but this has not been sufficiently investigated in risk assessment context. Here, exploration is utilized and followed by risk prioritization on chemical compounds that can potentially migrate to food from two paperboard FCM samples.
Concentration estimates from exploration are converted to tentative exposure assessment, while predicted chemical structures are assessed using quantitative structure-activity relationships (QSAR) models for carcinogenicity, mutagenicity, and reproductive toxicity. A selection of 60 chemical compounds from two FCMs is assessed by four risk assessors to classify compounds based on probable risk. For almost 60% of cases, the assessors classified compounds as either high priority or low priority.
Unclassified compounds are due to disagreements between experts (18%) or due to a perceived lack of data (23%). Among the high priority substances are high-concentration compounds, benzophenone derivatives, and dyes. The low priority compounds contained e.g. oligomers from plasticizers and linear alkane amides. The classification scheme provides valuable information based on tentative data and is able to prioritize discovered chemical compounds for pending risk assessment.
CONTINUE READING ON www.sciencedirect.com
This MUDP project was designed to develop a technology for the extraction of the non-magnetic metals from the wet, finely divided part of the combustion slag with a grain size less than 3 mm. Thus, the project will contribute to the desire to increase the recycling of non-magnetic metals.The project has shown that it is possible to sort non-magneti...
More than 20 percent of high school students use electronic cigarettes, risking nicotine addiction, lung damage and the temptation to try traditional smokes, U.S. health officials reported Thursday.Between 2011 and 2018, the number of high school teens who started vaping, as e-cigarette use is called, increased from 220,000 (1.5 percent) to just ov...
Takehome: On Nov. 12, China Association of Fragrance Flavor and Cosmetic Industries (CAFFCI) opened a public consultation on five draft group standards (including 2 guidelines and 3 cosmetic ingredients quality standards) on cosmetic safety assessment in line with a regulatory reform schedule which was detailed in an earlier ChemLinked report....
The study provides more knowledge about pro / prebiotic cosmetics in Denmark with regard to ingredients, products and market overview. Pro and prebiotic ingredients are well known as dietary supplements, and their definition is based on their use in food / dietary supplements. The common definition of "probiotic" involves the use of living mic...
Estefania Boix has published the review: "Interactions Between Metal Oxides and Biomolecules: From Fundamental Understanding to Applications" for the American Chemical Society. For three years, Estefania and her colleagues at Nottingham Trent University gathered and critically compared the latest discoveries on metal and metalloid ox...
2013 © MyChemicalMonitoring. ALL Rights Reserved. About Us | Terms and Conditions