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The International Agency for Research on Cancer (IARC) Monographs 133 contains the assessment on the carcinogenicity of four substances: 2-bromopropane, butyl methacrylate, anthracene, and dimethyl hydrogen phosphite.
According to the monograph, two of the substances, 2-bromopropane and butyl methacrylate, were evaluated by the working group for the first time. 2-bromopropane, a solvent used in dry cleaning and adhesive production, was classified as probably carcinogenic to humans (Group 2A), while butyl methacrylate, used in coatings, plastics, and healthcare materials, was classified as possibly carcinogenic to humans (Group 2B). Anthracene, a high-production-volume polycyclic aromatic hydrocarbon used in the manufacture of dyes, pigments, and pesticides, was also classified as possibly carcinogenic to humans. Dimethyl hydrogen phosphite, used in adhesives, lubricants, and pharmaceuticals, was also classified as possibly carcinogenic to humans.
The working group based their classifications on sufficient evidence of cancer in experimental animals and limited or inadequate mechanistic evidence. However, data on exposure levels were sparse, and no epidemiological studies on cancer in humans were available for any of the agents.
The publication of these findings highlights the importance of continued research and regulation in the use of these substances to minimize the risk of cancer in humans.
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