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UK REACH – Applications for authorisation AFA014-01 – OPnEO/NPnEO

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This news contains references also to other Substances

(*) 4-(1,1,3,3-Tetramethylbutyl)phenol, ethoxylated (Octylphenolethoxylates, OPnEO)  
(*) 4-Nonylphenol, branched and linear, ethoxylated (Nonylphenolethoxylates, NPnEO)

Proposed use: Use of OPnEO and NPnEO in 10 in vitro diagnostic (IVD) assays used for example in Clinical Chemistry (CC) and Drug Monitoring (DM) products

Broad information on use applied for (conditions of use and function): 

Octyl- and/or Nonylphenol ethoxylates are used in IVD kits due to their surface-active properties and are usually used as an auxiliary chemical in one or several liquid reagents used for each assay. Both substances may fulfil different functions during the performance of the assay. Typical functions are increasing solubilisation of reagents, cell lysis, protein stabilisation and as wetting agent. As already completed substitutions of OPnEO and NPnEO and experiences in the development of new products have shown, other surfactants can in principle be used to replace OPnEO and NPnEO in IVD assays.



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