CLP | 42 Hazard endpoints for which ECHA is inviting 3rd parties to submit comments



ECHA has begun testing for hazard endpoints of 42 substances

Substance nameEC NumberHazard endpoint for which vertebrate testing was proposed
3-chloropropyl)dimethoxymethylsilane 242-056-0Sub-chronic toxicity (90-day): oral
(R)-p-mentha-1,8-diene 227-813-5Reproductive toxicity (extended one-generation reproductive toxicity study)
1,2-Benzenedicarboxylic acid, benzyl C7-9-branched and linear alkyl esters701-339-3Reproductive toxicity (pre-natal developmental toxicity)
1,3-Propanediamine, N-[3-((C11-14, C13-rich)oxy)propyl]- branched acetate 931-295-2Sub-chronic toxicity (90-day): oral
1,4-dimethylpiperazine 203-412-0

Reproductive toxicity (pre-natal developmental toxicity)


Sub-chronic toxicity (90-day): oral

4-acetyl-2-[(acetyloxy)methyl]phenyl acetate 921-042-4Genetic toxicity in vivo

1-ethoxy-2-(2-methoxyethoxy)ethane 


213-690-5

Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant.


Reproductive toxicity (pre-natal developmental toxicity)


Sub-chronic toxicity (90-day): oral



2,2-dimethyl-1,3-dioxolan-4-ylmethanol 

202-888-7

Reproductive toxicity (extended one-generation reproductive toxicity study)


Reproductive toxicity (pre-natal developmental toxicity)

2,3-epoxypropyl neodecanoate247-979-2

Reproductive toxicity (extended one-generation reproductive toxicity study)


Reproductive toxicity (pre-natal developmental toxicity)

2,4,6,8,10-pentamethylcyclopentasiloxane 228-204-7Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with 2,4,6,8-tetramethylcyclotetrasiloxane (EC 219-137-4)
2,4,6,8-tetramethylcyclotetrasiloxane 219-137-4Reproductive toxicity (extended one-generation reproductive toxicity study)
2-ethyl-2-[[(1-oxoallyl)oxy]methyl]-1,3-propanediyl diacrylate 239-701-3

Reproductive toxicity (extended one-generation reproductive toxicity

study)


Sub-chronic toxicity (90-day): oral

4,4''-isopropylidenedi-o-cresol 201-240-0Genetic toxicity in vivo

[1,3-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide 

218-664-7Reproductive toxicity (extended one-generation reproductive toxicity study) “|| Note: testing proposed with [1,3(or 1,4)-phenylenebis(1-methylethylidene)]bis[tert-butyl] peroxide CAS: 25155-25-3)”
Ashes (residues), nonhazardous municipal solid waste937-417-0

Reproductive toxicity (pre-natal developmental toxicity)


Sub-chronic toxicity (90-day): oral

choline hydroxide 204-625-1Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with Choline chloride (EC 200-655-4)
dichlorobis(?-cyclopentadienyl)titanium 215-035-9Genetic toxicity in vivo
dimethoxymethylsilane 240-914-9Sub-chronic toxicity (90-day): oral

dipotassium bis[µ-[tartrato(4-)-O1,O2:O3,O4]]diantimonate(2-) , stereoisomer 

234-293-3

Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant.


Reproductive toxicity (pre-natal developmental toxicity)

Distillates (petroleum), hydrodesulfurized middle 

265-183-3Genetic toxicity in vivo
Distillates (petroleum), hydrotreated middle 265-148-2Genetic toxicity in vivo
Gas oils (petroleum), hydrodesulfurized 265-182-8Genetic toxicity in vivo
hexadecyltrimethoxysilane 240-464-3Reproductive toxicity (extended one-generation reproductive toxicity study)
Lithium phosphorodifluoridate 643-080-8Reproductive toxicity (pre-natal developmental toxicity)
lithium tetrafluoroborate, anhydrous 238-178-9Genetic toxicity in vivo

N'-(1,3-dimethylbutylidene)-3-hydroxy-2-naphthohydrazide 

435-860-1

Reproductive toxicity (pre-natal developmental toxicity)


Sub-chronic toxicity (90-day): oral

N-(2-hydroxyethyl)-N-[2-[(1-oxooctyl)amino]ethyl]-ß-alanine 264-761-2Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with Amphoacetates C8-C18 (EC 931-291-0) || Note: Testing proposal is based on concern identified by the registrant.

p-tert-butylstyrene 

217-126-9Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant.
Phosphoric acid, 2-ethylhexyl ester 235-741-0Reproductive toxicity (pre-natal developmental toxicity)
Platinum(IV) aqua hydroxo nitrato complexes 701-319-4Genetic toxicity in vivo
Platinum,1,3-diethenyl-1,1,3,3- tetramethyldisiloxane and its platinum(0) complexes 701-315-2Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant.
Reaction mass of 4,4,13,13-tetraethoxy-3,14-dioxa-8,9-dithia-4,13-disilahexadecane and 4,4,14,14-tetraethoxy-3,15-dioxa-8,9,10-trithia-4,14-disilaheptadecane 915-748-1Sub-chronic toxicity (90-day): oral || Note: testing proposed with polysulfides, bis[3-(triethyoxysilyl)propyl (CAS No 211519-85-6)
Reaction mass of sodium 1-methoxy-1-oxohexadecane-2-sulphonate and sodium methyl 2-sulphooctadecanoate 911-616-2Sub-chronic toxicity (90-day): oral
sodium 1-hydroxyethanesulphonate 213-037-4Genetic toxicity in vivo
triethoxy(methyl)silane 217-983-9Sub-chronic toxicity (90-day): oral

zinc bis(benzenesulphinate) 

246-148-1Genetic toxicity in vivo


Link to the Hazard Endpoint Testing

                   

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