EU-funded EDC-MixRisk Project Highlights Importance of Considering Combined Exposure to Multiple Chemicals



We are exposed to multiple man-made chemicals from various sources. The EDC-MixRisk research project, coordinated by Karolinska Institutet, Swetox, emphasizes the need to address the effects of chemicals as mixtures in order not to underestimate the risks they pose. The current risk assessment paradigm seems to be falling short as it is largely based on considering one chemical at a time.

The EDC-MixRisk research project studies the effects of endocrine-disrupting chemicals (EDCs), focusing on EDC-mixtures and their effects on the developing foetus. Endocrine disruptors are chemicals that interfere with our hormonal system, and they have been linked to various diseases and disorders, e.g., infertility, cancer, obesity and impaired neurodevelopment.

EDCs are ubiquitous contaminants in our environment as they can be found in everyday products, such as in plastic bottles, toys, cosmetics, electronics, textiles and even in food as pesticide residues and as additives in food contact materials. The chemicals used in various products and materials leak and migrate to the environment reaching also us, human beings.

“To study effects of these chemicals in mixtures, we used real-life exposure data from the Swedish SELMA pregnancy cohort to see which chemicals the mothers and their children were exposed to, and identified EDC mixtures in prenatal urine and blood that were associated with adverse health outcomes in the children as a first step,” explains Carl-Gustaf Bornehag, Professor in Public Health Sciences at Karlstad University, Sweden.

“Based on the chemicals measured in mothers’ serum and urine, we established reference chemical mixtures in the project. They were then tested in experimental models for potential adverse effects in terms of growth and metabolism, neurodevelopment and sexual development,” he continues.

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