EFSA MIXTOX guidance document | Animal Health Risk assessment of multiple chemicals in essential oils for farm animals

This technical report implements the EFSA MIXTOX guidance document for animal health risk assessment of combined exposure to multiple chemicals in essential oilsusing whole mixture and component‐based approaches (WMA and CBA).The harmonised step wise approaches from the MIXTOX guidance are applied to the problem formulation, exposure assessment, hazard assessment and risk characterisation using conservative scenarios, available data and tools. Options for the refinement of the CBA are proposed for the exposure assessment and hazard assessment (toxicity and toxicokinetic data and models) steps as well as for the application of risk characterisation methods.

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