The European Chemicals Agency’s (ECHA) Risk Assessment Committee (RAC) recently published its full opinion, confirming the conclusion from its March 2018 meeting that di-isononyl phthalate (DINP) does not warrant classification for reproductive and developmental toxicity effects under the European Union’s Classification, Labelling and Packaging regulation. The CLP regulation is the EU implementation of the UN Globally Harmonized System (GHS).
The RAC opinion rejected by consensus the proposed classification of DINP as a reproductive toxicant category 1B (Development) and Category 2 (Fertility) and concluded “no classification for DINP for either effects on sexual function and fertility, or for developmental toxicity is warranted.” The ruling followed an extensive evaluation of existing toxicity data on DINP, including two reproductive (fertility) toxicity studies, 13 developmental toxicity studies, 15 repeat-dose toxicity studies – all in animals – and eight epidemiological studies in humans. The American Chemistry Council’s (ACC) High Phthalates Panel issued the following statement about ECHA’s conclusion:
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