Triclosan worsens fatty liver disease in mice

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NIEHS-funded researchers at the University of California (UC) San Diego found evidence that triclosan — an antimicrobial found in medical soaps and household products — worsens fatty liver disease in mice that ate a high-fat diet.

The authors also uncovered molecular mechanisms by which triclosan strips away liver cells’ natural protections and disrupts both metabolism and the gut microbiome. The study was published Nov. 23 in Proceedings of the National Academy of Sciences.

“The significance of this study lies in the fact that the ubiquitous presence of the environmental contaminant triclosan in conjunction with the prevalence of high consumption of dietary fat ... are common factors encountered in everyday life,” the authors wrote.



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