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Human Risk Assessment (RA) of combined exposure to multiple chemicals follows the steps of RA namely problem formulation, exposure assessment, hazard assessment and risk characterisation. Over the last decade, scientific advisory bodies have published a range of harmonised guidance documents to provide practical approaches for risk assessors. These include the WHO, the US‐EPA, the Joint Research Centre (JRC) of the European Commission, the OECD and the recent EFSA MIXTOX guidance document dealing with harmonised methodologies for the human health, animal health and ecological RA areas.
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