ECHA | Database containing mammalian elimination half-lives now published

Elimination half-lives in mammals, including humans, have been proposed as a potential complementary metric to expand the assessment of bioaccumulative properties to cover air-breathing organisms. To explore the possibilities of using such data in bioaccumulation assessment and predictions, human and terrestrial mammalian elimination half-life data has been collected along with physiochemical data and parameters. The database will facilitate looking up toxicokinetic data and finding respective studies.

This first version of the mammalian toxicokinetic database contains elimination half-life values for around 1 400 substances collected from publications and publicly available studies.

The data was collected by Norwegian Institute of Public Health (NIPH) together with ECHA during 2016-2020.

Source: ECHA Newsletter