European Commission | Advanced Non-animal Models in Biomedical Research


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A study was initiated at the JRC to develop a current overview of available and emerging non-animal models in the field of Respiratory Tract Diseases. In a literature review, over 21,000 abstracts (11,636 non-cancer and 9,421 cancer) were scanned for relevant non-animal methods of respiratory disease. From this, a total of 284 publications were finally identified as being promising candidate methods according to a set of inclusion/exclusion criteria. In vitro cell and tissue cultures, human ex vivo, in silico approaches were chiefly considered. These methods have been collated into a catalogue of biomedical disease models that will form a key knowledge source for researchers, educators and national ethics and funding authorities. The availability of a centralised source of reviewed methods will contribute to extend the requirements of EU Directive 2010/63/EU on the protection of animals used for scientific purposes to biomedical science. 

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