Medicines Pesticides & HEAL alert: Letter concerning cyprodinil, mepanipyrim and pyrimethanil

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Our organizations hereby wish to draw your attention to the situation of three fungicides cyprodinilmepanipyrim andpyrimethanil, respectively - whose authorizations expire in 2020, even if a possible administrative extension concerning mepanipyrim and pyrimethanil was to the agenda of the February 18 pesticides committee (Standing Committee on Plants, Animals, food and feed or ScoPAFF).

In our view, the registrations of these three fungicidal substances, which are part of the family of anilinopyrimidines, should not be renewed, for the following reasons:

(*) First of all, these substances are on the list of thyroid endocrine disruptors (EP) suspects on which we alerted you in June 2019 and which we presented to ANSES on 28 October 2019. This list is taken from the cross of the list of pesticides with activity thyroid by the European Food Health Agency (EFSA) in 2013, and that established by ANSES on the contaminants found in food in its Study of total food French (Eat2 tome 2, June 2011). There are two of these substances, cyprodinil and pyrimethanil among contaminants in infant food (see EAT i), cyprodinil being one of the 11 substances detected in more than 10% of the samples.

(*) In addition, a very recent publication has highlighted the neurotoxic role that could have these substances in the aggravation of Alzheimer's disease in animals. The robustness of this study is linked to the criteria and biomarkers selected and studied for Alzheimer's disease even if the study involves rodents. This publication is the result of joint work between INSERM, CNRS and LipSTIC LabEx. In this study, exposure to these fungicides corresponds to regulatory rates allowed in drinking water (0.1 µg / l) and long-term exposure (6 to 9 months in models).

(*)Lastly, in the case of pyrimethanil, we remind you of our letter of September 20, 2019 in which we told you about our concerns about possible contamination by aerial of the population of Saint Estephe (33) at certain times, at doses of 2.1 µg of pyrimethanil per 24 hours.

We therefore request that ANSES make its opinion public, especially since France is the designated reporting State in the case of Cyprodinil.

In the spirit of the recommendations of the second national strategy on disruptors endocrine (SNPE2), fighting to reduce PE exposure through food a priority, we also expect the Ministry to communicate transparently the position adopted during the discussions and votes concerning the re-approvals that will take place within of the European ScoPAFF committee in charge of the final decision.

Despite a probable administrative extension for two of these three substances, the decision concerning cyprodinil remains pending. A strong and transparent position on the part of France remains important in order to promote the health of the European population.

For both associations, the President of AMLP



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