OECD | Ability of biopersistent/biodurable manufactured nanomaterials (MNs) to induce lysosomal membrane permeabilization (LMP)


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This document describes the expanding knowledge on the implications and biological significance of lysosomal and autophagy dysfunction and the subsequent assembly and activation of inflammasome NLRP3 induced by biodurable manufactured nanomaterials.

Lysosomal membrane permeabilization (LMP) and lysosomal and autophagy dysfunction with inflammasome activation has a profound impact on cell homeostasis, resulting in manifold pathological situations, including infectious diseases, neurodegeneration, aging as well as fibrotic diseases and cancer.

Link to the OECD | Ability of biopersistent/biodurable manufactured nanomaterials (MNs) to induce lysosomal membrane permeabilization (LMP)

                   

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