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ECHA updates recommendations to improve REACH registrations

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Helsinki, 28 February 2023 - The recommendations for registrants are based on ECHA’s findings from registration dossier compliance checks and take recent changes to REACH information requirements into account. Companies should review the recommendations to make sure their dossiers comply with the law and ensure the safe use of their chemicals. 

The recommendations focus on the rules for using adaptations to assess the safety of chemicals without animal testing. They provide advice on read across, which uses information from a source substance to predict the properties of a similar target substance. This advice covers considerations on structural similarity, defining substance groups, and predicting target substance properties. 

Information is also available on adaptations that are based on exposure scenarios outlined in chemical safety reports. Further advice addresses the requirements for mutagenicity information and chronic aquatic toxicity studies for poorly soluble substances. 


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