Titanium dioxide in nanoparticle form: ANSES defines a toxicity reference value (TRV) for chronic inhalation exposure

Titanium Dioxide in nanoparticle form (TiO2-NP) is used in many industrial and commercial applications. ANSES was asked to define a toxicity reference value (TRV) for this substance as part of its national mission to develop health reference values. Following an in-depth analysis of all the available toxicity data, the Agency is recommending a chronic TRV by inhalation for the P25 form of TiO2-NP of 0.12 µg/m-3. This reference value will be used when conducting health risk assessments as part of the management of industrial facilities and sites in France. It is also the first TRV developed for a nanomaterial in France. 



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