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  • November 29, 2022
  • EFSA

EFSA | Re-evaluation of neohesperidine dihydrochalcone (E 959) as a food additive

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The present opinion deals with the re‐evaluation of neohesperidine dihydrochalcone  (E 959) when used as a food additive. It is obtained by catalytic hydrogenation of a flavanone – neohesperidine – which is naturally occurring and thus isolated by alcohol extraction in bitter oranges (Citrus aurantium). Based on in vivo data in rat, neohesperidine dihydrochalcone is likely to be absorbed, also in humans, and to become systemically available. It does not raise a concern regarding genotoxicity. The toxicity data set consisted of studies on subchronic and prenatal developmental toxicity.



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