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  • January 16, 2024
  • WTO

United States of America | Per- and Poly-Fluoroalkyl Chemical Substances Designated as Inactive on the TSCA Inventory; Significant New Use Rule

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Title of document
Per- and Poly-Fluoroalkyl Chemical Substances Designated as Inactive on the TSCA Inventory; Significant New Use Rule

Under the Toxic Substances Control Act (TSCA), EPA is finalizing a significant new use rule (SNUR) for 329 per- and poly-fluoroalkyl substances (PFAS) that are designated as inactive on the TSCA Chemical Substance Inventory. PFAS are a group of chemicals that have been used in industry and consumer products since the 1940s because of their useful properties, such as water and stain resistance. Many PFAS break down very slowly and can build up in people, animals, and the environment over time. Exposure at certain levels to specific PFAS can adversely impact human health and other living things. Persons subject to the final SNUR are required to notify EPA at least 90 days before commencing any manufacture (including import) or processing of the chemical substance for a significant new use. Once EPA receives a notification, EPA must review and make an affirmative determination on the notification, and take such action as is required by any such determination before the manufacture (including import) or processing for the significant new use can commence. Such a review will assess whether the new use may present unreasonable risk to health or the environment and ensure that EPA takes appropriate action as required to protect health or the environment.Title 40 Code of Federal Regulations (CFR) Parts 9 and 721This final rule and the proposed rule notified as G/TBT/N/USA/1960 are identified by Docket Number EPA-HQ-OPPT-2022-0867. The Docket Folder is available from at and provides access to primary and supporting documents as well as comments received. Documents are also accessible from by searching the Docket Number. 

Notifying member: United States of America


Objective tag
Protection of human health or safety (TBT); Protection of animal or plant life or health (TBT); Protection of the environment (TBT)



  • Submission: N/A
  • Reception: N/A
  • Distribution: 12/01/2024
  • Final date for comments: N/A
  • Proposed date of adoption: N/A


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