OECD | Final Project Report and Recommendations with Methodology to Prioritise Key Events (KEs) Relevant for Manufactured Nanomaterials

Adverse Outcome Pathways (AOPs) are conceptual frameworks that link key events (KEs) resulting from chemical or material exposure to adverse health or environmental impacts (Adverse Outcomes; AOs) important for evaluating safety. AOPs are designed as frameworks to organize toxicological information and offer a systematic and mechanistic approach to develop, assess, use, and interpret alternative testing strategies as part of Integrated Approaches to Testing and Assessment (IATA). Applied to IATA, AOPs are ultimately expected to reduce reliance on animal testing and are anticipated to be useful in risk assessment by linking alternative testing to health and environmental effects of nanomaterials and other emerging substances in a more systematic way.

Link to the OECD | Final Project Report and Recommendations with Methodology to Prioritise Key Events (KEs) Relevant for Manufactured Nanomaterials