When are adverse outcome pathways and associated assays "Fit for Purpose" for regulatory decision-making and management of chemicals?



ABSTRACT - There have been increasing demands for chemical hazard and risk assessments in recent years.

Chemical companies have expanded internal product stewardship initiatives, and jurisdictions have increased the regulatory requirements for the manufacture and sale of chemicals.

There has also been a shift in chemical toxicity evaluations within the same timeframe with new methodologies being developed to improve chemical safety assessments for both human health and the environment.

With increased needs for chemical assessments coupled with more diverse data streams from new technologies, regulators and others tasked with chemical management activities are faced with increasing workloads and more diverse types of data to consider.

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