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Highlights
(*) Overview of existing large, comprehensive nanomaterial grouping frameworks and other useful nanomaterial grouping approaches
(*) Comparison of grouping principles, advantages/disadvantages of each approach and an assessment of (regulatory) applicability
(*) Improvements achieved within the European H2020 Project NanoReg2
(*) Challenges for putting grouping into practice based on NanoReg2 case studies including recommendations to overcome them
(*) Outlook with respect to open research needs for putting grouping into practice
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