Evaluation of in vitro methods for human hazard assessment applied in the OECD Testing Programme for the Safety of Manufactured Nanomaterials
The OECD Joint Meeting of the Chemicals Committee and Working Party on Chemicals,
Pesticides and Biotechnology (the Joint Meeting) held a Special Session on the Potential
Implications of Manufactured Nanomaterials for Human Health and Environmental
Safety (June 2005). This was the first opportunity for OECD member countries, together
with observers and invited experts, to begin to identify human health and environmental
safety related aspects of manufactured nanomaterials. The scope of this session was
intended to address the chemicals sector.
As a follow-up, the Joint Meeting decided to hold a Workshop on the Safety of
Manufactured Nanomaterials in December 2005, in Washington, D.C. The main objective
was to determine the “state of the art” for the safety assessment of manufactured
nanomaterials with a particular focus on identifying future needs for risk assessment
within a regulatory context.
Based on the conclusions and recommendations of the Workshop
[ENV/JM/MONO(2006)19] it was recognised as essential to ensure the efficient
assessment of manufactured nanomaterials so as to avoid adverse effects from the use of
these materials in the short, medium and longer term. With this in mind, the OECD
Council established the OECD Working Party on Manufactured Nanomaterials (WPMN)
as a subsidiary body of the OECD Chemicals Committee in September 2006. This
programme concentrates on human health and environmental safety implications of
manufactured nanomaterials (limited mainly to the chemicals sector), and aims to ensure
that the approach to hazard, exposure and risk assessment is of a high, science-based, and
internationally harmonised standard. It promotes international co-operation on the human
health and environmental safety of manufactured nanomaterials, and involves the safety
testing and risk assessment of manufactured nanomaterials.
This project, which was approved for inclusion in the WPMN work plan, was led by the
Joint Research Centre (JRC) and the International Council for Animal Protection in
OECD Programmes (ICAPO). The purpose of this evaluation was to review the dossiers
of the Testing Programme and to evaluate which of the existing in vitro OECD Test
Guidelines (TGs) were used, what other non-guideline methods were applied, and what
were the potential limitations of each assay used for testing manufactured nanomaterials
This document is published under the responsibility of the Joint Meeting of the Chemicals
Committee and Working Party on Chemicals, pesticides and Biotechnology of the OECD.
Link to the OECD Report "Evaluation of in vitro methods for human hazard assessment applied in the OECDTesting Programme for the Safety of Manufactured Nanomaterials"