ECHA | 57th Meeting of the Committee for Risk Assessment (RAC-57) | 29 June 2021 | Minutes



The Minutes of the 57th Meeting of the Committee for Risk Assessment (RAC-57) includes the following scientific topic(s) for discussion:

6. Request under Article 77(3)(c)

6.1. Classification for environmental toxicity of lead

7. Health based exposure limits at the workplace

Asbestos – final draft opinion

8. Harmonised classification and labelling (CLH)

8.2 CLH dossiers

8.2.1 Hazard classes for agreement without plenary debate

- Reaction mass of 1-(2,3-epoxypropoxy)-2,2-bis ((2,3-epoxypropoxy)methyl) butane and 1-(2,3-epoxypropoxy)-2-((2,3-epoxypropoxy)methyl)-2-hydroxymethyl butane (EC: -; CAS: -): germ cell mutagenicity, reproductive toxicity (discussed in the CLH WG)

- Sodium chlorate (EC: 231-887-4; CAS: 7775-09-9): acute oral toxicity, hazardous to the aquatic environment (discussed in the CLH WG)

- Potassium chlorate (EC: 223-289-7; CAS: 3811-04-9): acute oral and inhalation toxicity, hazardous to the aquatic environment (discussed in the CLH WG)

- Triethylamine (EC: 204-469-4; CAS: 121-44-8): acute inhalation and dermal toxicity, serious eye damage/eye irritation (discussed in the CLH WG)

- Di-n-butylamine (EC: 203-921-8; CAS: 111-92-2): acute oral, dermal and inhalation toxicity, skin corrosion/irritation, serious eye damage/eye irritation, STOT SE (discussed in the CLH WG)

- Difenoconazole (ISO): physical hazards, acute dermal and inhalation toxicity, skin sensitisation, skin corrosion/irritation, serious eye damage/eye irritation, germ cell mutagenicity, STOT SE, hazardous to the aquatic environment

- 4-Nitrosomorpholine: carcinogenicity

- N,N-dimethyl-p-toluidine: acute toxicity via all routes, germ cell mutagenicity

- Metribuzin (ISO): acute toxicity via all routes, skin irritation, serious eye damage/eye irritation, respiratory sensitisation, skin sensitisation, germ cell mutagenicity, carcinogenicity, reproductive toxicity, STOT SE

- Lithium carbonate; lithium chloride; lithium hydroxide: germ cell mutagenicity, carcinogenicity

8.2.2 Substances with hazard classes for agreement in plenary session

- Reaction mass of 1-(2,3-epoxypropoxy)-2,2-bis ((2,3-epoxypropoxy)methyl) butane and 1-(2,3-epoxypropoxy)-2-((2,3-epoxypropoxy)methyl)-2-hydroxymethyl butane (EC: -; CAS: -) – developmental toxicity

Triethylamine (EC: 204-469-4; CAS: 121-44-8) – acute oral toxicity

Difenoconazole (ISO); 1-({2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3- dioxolan-2-yl}methyl)-1H-1,2,4-triazole; 3-chloro-4-[(2RS,4RS;2RS,4SR)-4- methyl-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-2-yl]phenyl 4-chlorophenyl ether (CAS: 119446-68-3)

4-Nitrosomorpholine (EC: 627-564-6; CAS: 59-89-2)

N,N-dimethyl-p-toluidine (EC: 202-805-4; CAS: 99-97-8)

Metribuzin (ISO); 4-amino-6-tert-butyl-3-methylthio-1,2,4-triazin-5(4H)-one; 4- amino-4,5-dihydro-6-(1,1-dimethylethyl)-3-methylthio-1,2,4-triazin-5-one (EC: 244-209-7; CAS: 21087-64-9)

- [1] Lithium carbonate; [2] lithium chloride; [3] lithium hydroxide (EC: [1] 209-062- 5; [2] 231-212-3; [3] 215-183-4; CAS: [1] 554-13-2; [2] 7447-41-8; [3] 1310-65- )

Nonylphenol, branched and linear, ethoxylated (with average molecular weight < 352 g/mol) [includes ortho-, meta-, para- isomers or any combination thereof] (EC: 500-315-8; 500-024-6; 500-045-0; 500-209-1; 248-762-5; 243-816-4; 248-291- 5; and others; CAS: 127087-87-0; 9016-45-9; 26027-38-3; 68412-54-4; 27986- 36-3; 20427-84-3; 27176-93-8; 1119449-38-5 and others)

Nonylphenol, branched and linear, ethoxylated (with 352 g/mol ≤ average molecular weight < 704 g/mol) [includes ortho-, meta-, para- isomers or any combination thereof] (EC: 230-770-5; 248-743-1; 247-555-7; 248-293-6 and others; CAS: 127087-87-0; 9016-45-9; 7311-27-5; 27942-27-4; 26264-02-8; 27177-05-5; 14409-72-4 and others)

Nonylphenol, branched and linear, ethoxylated (with 704 g/mol ≤ average molecular weight ≤ 1540 g/mol) [includes ortho-, meta-, para- isomers or any combination thereof] (EC: -; CAS: 127087-87-0; 9016-45-9 and others)

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